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Dr. Yaariv Khaykin
Dr. Yaariv Khaykin
Clinical Electrophysiology
Staff Cardiologist


Doctor of Medicine, General Internal Medicine Program at the University of Toronto, Cardiology Program at the University of Toronto and Electrophysiology, Fellowship at the Cleveland Clinic Foundation.

Associations and Affiliations:

Royal College of Physicians and Surgeons of Canada, Heart Rhythm Society, Canadian Cardiovascular Society, Canadian Heart Rhythm Society, American College of Cardiology, and the American Heart Association

Research Focus:

Throughout his years as an electrophysiologist, Dr. Khaykin has always expressed an interest in the different approaches to ablation and invasive treatment for atrial fibrillation and ventricular tachycardia. This ties in closely with Dr. Khaykin's clinical work of dealing with patients with complex cardiac arrhythmias. As an integral part of the complex ablation program at Southlake, Dr. Khaykin tracks the outcomes of these procedures and pioneers clinical practice using new device and ablation technologies.This particular research focus helps the Southlake Heart Rhythm Program provide quality assurance in order to ensure consistently good outcomes and low complication rates as well as improve productivity and lower exposure to fluoroscopy for the patients and the staff.

As an international researcher, Dr. Khaykin also focuses on health economics, since his procedures are often quite expensive with costly equipment. Dr. Khaykin has published several papers regarding the long-term cost to the system of treating patients with new and costly invasive therapy, comparing that to conventional medical therapy. His research concluded that invasive therapy actually breaks even after two to three years and leads to cost-savings beyond that. Based on this research, dedicated funding for complex ablation procedures was made available.

Research Summary of Key Projects:

When Dr. Khaykin returned back to Toronto from Cleveland he brought with him two projects focusing on the different approaches to ablation for atrial fibrillation. During these studies, Dr. Khaykin was able to start the complex ablation program, performing 50 of these high-end procedures in his first year of practice. Today, Southlake is one of the highest volume complex ablation centers in Canada.

Dr. Khaykin has conducted research studies comparing conventional biventricular pacing with fusion pacing of the left ventricle alone in patients with a history of congestive heart failure. This research has lead to the development of a novel algorithm allowing the right lower chamber of the heart to activate naturally, while preserving pacemaker battery and improving longevity of the device.

Dr. Khaykin was the first operator in the world to use Cartosound; a technology placed inside the heart so the operator can see the heart chambers in real time using ultrasound and perform 3D reconstructions of any of the heart chambers for ablation.

Research Goals:

Dr. Khaykin has been a lead researcher on a number of projects where Southlake has received new cutting-edge technology from industry partners before any other organization. After testing the new technologies, he is asked to share and publish his experiences.

Currently, Dr. Khaykin is participating in a study on a special type of high-density mesh ablation catheter. Instead of using a conventional point-by-point ablation catheter, Dr. Khaykin is creating lesions with the novel catheter around the entire perimeter of the mesh – encompassing the entire pulmonary vein at once.

Future Goals and Interest in Research:

Dr. Khaykin is interested in medical informatics and is currently involved in several projects at Southlake as well as nationally. He is starting several new projects assessing the use of new catheters that are able to record the amount of pressure delivered to the tissue using ablation or the effective contact between the catheter and the tissue. The initial goal of this research will allow Dr. Khaykin to be able to predict completeness of the lesions, while improving procedural safety both for atrial fibrillation and ventricular tachycardia.

Recent Scholarships and Awards:

2012 Researcher Award of ExcellenceSouthlake Regional Health Centre

Related Articles and Publications:

Cost Considerations in the Management of Atrial Fibrillation - Impact of Dronedarone.

Point-By-Point Pulmonary Vein Antrum Isolation Guided by Intracardiac Echocardiography and3D Mapping and Duty-Cycled Multipolar AF Ablation: Effect of Multi-polar Ablation on Procedure Duration And Fluoroscopy Time.

Sex Differences in Implantable Cardioverter-Defibrillator Outcomes: Findings from a Prospective Defibrillator Database.

Adenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination (ADVICE): Methods and Rationale.

The Real Cost of Treating Atrial Fibrillation


Ablation of Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Arrhythmia-Free Survival After Endo-Epicardial Substrate Based Mapping and Ablation.

Clinical Predictors of Arrhythmia Recurrences Following Pulmonary Vein Antrum Isolation for Atrial Fibrillation: Predicting Arrhythmia Recurrence Post-PVAI.

Adjusting the Timing of Left-Ventricular Pacing Using Electrocardiogram and Device Electrograms

Is There an Association Between External Cardioversions and Long-Term Mortality and Morbidity? Insights from the Atrial Fibrillation Follow-Up Investigation of Rhythm Management Study.

CARTO-Guided Vs. Navx-Guided Pulmonary Vein Antrum Isolation and Pulmonary Vein Antrum Isolation Performed Without 3-D Mapping: Effect of the 3-D Mapping System on Procedure Duration and Fluoroscopy Time.

Cost of AF Ablation: Where Do We Stand?

Prevalence and Risk Factors for Cervical and Lumbar Spondylosis in Interventional Electrophysiologists

Predictors of Short Term Complications after ICD Replacement: Results from the Ontario ICD Database.

Incidence of Very High Defibrillation Thresholds (DFT) and Efficacy of Subcutaneous (SQ) Array Insertion during Implantable Cardioverter Defibrillator (ICD) Implantation.

Periprocedural Stroke and Management of Major Bleeding Complications in Patients Undergoing Catheter Ablation Of Atrial Fibrillation: The Impact Of Periprocedural Therapeutic International Normalized Ratio

Substrate andTrigger Ablation forReduction ofAtrial Fibrillation (STAR AF): A Randomized, Multicentre, International Trial

Atrial Fibrillation Termination asa Procedural Endpoint during Ablation in Long-Standing Persistent Atrial Fibrillation

Evaluation of Early Complications Related to De Novo Cardioverter Defibrillator Implantation Insights from the Ontario ICD Database

Incidence of Left Ventricular Function Improvement After Primary Prevention ICD Implantation for Non-Ischemic Dilated Cardiomyopathy: A Multicenter Experience

A Randomized Controlled Trial of the Efficacy and Safety of Electroanatomical Circumferential Pulmonary Vein Ablation Versus Potential-Guided Pulmonary Vein Antrum Isolation Guided by Intracardiac Ultrasound.

Dofetilide is Safe and Effective in Preventing Atrial Fibrillation Recurrences in Patients Accepted for Catheter Ablation

Predictors of Appropriate Implantable Cardioverter Defibrillator (ICD) Therapy in Primary Prevention Patients with Ischemic and Nonischemic Cardiomyopathy.

Impact Of Type of Atrial Fibrillation and Repeat Catheter Ablation on Long-Term Freedom from Atrial Fibrillation: Results from a Multicenter Study

Atrial Fibrillation Ablation Strategies for Paroxysmal Patients: Randomized Comparison Between Different Techniques.

Masquerading Tachycardia

Impact of AV Conduction Disorders on Safer Mode Performance.

Review on "High-Density Mapping of Atrial Fibrillation in Humans: Relationship Between High-Frequency Activation and Electrogram Fractionation".

Ablation for Longstanding Permanent Atrial Fibrillation: Results from a Randomized Study Comparing Three Different Strategies

Cost Comparison of Ablation Versus Antiarrhythmic Drugs as First Line Therapy for Atrial Fibrillation: an Economic Evaluation of the RAAFT Pilot Study.

Real Time Integration of 2D Intracardiac Echocardiography and 3D Electroanatomical Mapping to Guide Ventricular Tachycardia Ablation.

Intracardiac ECHO Integration with Three Dimensional Mapping: Role in AF Ablation.

Design and Implementation of a Population-Based Registry of Implantable Cardioverter Defibrillators (ICDs) in Ontario.

Spatial and Temporal Stability of Complex Fractionated Electrograms in Patients with Persistent Atrial Fibrillation over Longer Time Periods: Relationship to Local Electrogram Cycle Length.

Complications Associated with Defibrillation Threshold Testing: The Canadian Experience.

A Prospective, Multicenter Evaluation of Ablating Complex Fractionated Electrograms (CFEs) During Atrial Fibrillation (AF) Identified By An Automated Mapping Algorithm: Acute Effects on AF and Efficacy as an Adjuvant Strategy.

First Human Experience with Real-Time Integration of Intracardiac Echocardiography and 3D Electroanatomical Imaging to Guide Right Free Wall Accessory Pathway Ablation.

Cost Comparison of Catheter Ablation and Medical Therapy in Atrial Fibrillation.

Cost-Effectiveness of Catheter Ablation for Atrial Fibrillation.

Incidence of Atrial Fibrillation in Heart Transplant Patients: Long-Term Follow-Up.

Residual High Incidence of Ventricular Arrhythmias after Left Ventricular Reconstructive Surgery

Delayed Lead Perforation: A Disturbing Trend.

Response to Pharmacological Challenge of Dissociated Pulmonary Vein Rhythm.

Impact of Coronary Sinus Lead Position on Biventricular Pacing: Mortality and Echocardiographic Evaluation During Long-Term Follow-Up

Remote Interrogation and Monitoring of Implantable Cardioverter Defibrillators

Pulmonary Vein Isolation for Atrial Fibrillation in Patients with Symptomatic Sinus Bradycardiaor Pauses

Pulmonary Vein Antrum Isolation for Treatment of Atrial Fibrillation in Patients with Moderate Valve Disease or Prior Cardiac Surgery

Pulmonary Vein Isolation for the Treatment of Atrial Fibrillation in Patients with Impaired Systolic Function

Impact of Age on the Outcome of Pulmonary Vein Isolation for Atrial Fibrillation Using Circular Mapping Technique and Cooled-Tip Ablation Catheter

Pulmonary Vein Isolation for Treatment of Atrial Fibrillation in Patients with Structural Heart Disease

Pacing in Heart Failure: The Benefit of Resynchronization

Dorian P. Biphasic Cardioversion in Shock-Resistant Atrial Fibrillation: A Randomized Clinical Trial

Processes and Outcomes of Care for Diabetic Acute Myocardial Infarction Patients in Ontario: do Physicians under Treat?

Correlates of Therapeutic Response in Panic Disorder Presenting with Palpitations: Heart Rate Variability, Sleep and Placebo Effect.

Electrophysiological Mechanisms for Atrial Fibrillation Onset And Interruption: How Could Pacing Interfere?

Acute Thrombocytopenia Associated with Eptifibatide Therapy.

Utilization of Coronary Angiography after Acute Myocardial Infarction in Ontario Over Time: Have Referral Patterns Changed?

The Effect of Sinus Node Depression on Heart Rate Variability in Humans Using Zatebradine, a Selective Bradycardic Agent

Autonomic Correlates of Antidepressant Treatment Using Heart Rate Variability Analysis.

End-To-End Cyclization of aPyrene End-Capped Poly(Bisphenol AF-Diethylene Glycol Carbonate) in Solution

Characterization of the Core of Polystyrene Block Poly(Methyl Methacrylate) Polymer Micelles By Energy Transfer.

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